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将大鼠置于模拟海拔８ｋｍ高度的低压舱内缺氧１周及缺氧后空气中常氧恢复１周和２周，观察了左右心室功能、心肌肥厚、心肌收缩蛋白含量及其Ｃａ￣（２＋），Ｍｇ￣（２＋）－ＡＴＰ酶活性的动态变化。结果表明，８ｋｍ缺氧１周后肺动脉压及右心室收缩压明显升高，左右心室±ｄｐ／ｄｔｍａｘ及收缩指数明显降低。左右心室肌明显肥厚，心肌收缩蛋白Ｃａ￣（２＋），Ｍｇ￣（２＋）－ＡＴＰ酶活性明显减低。缺氧后常氧恢复１和２周后，左右心室功能逐渐恢复达到或接近正常水平，心肌肥厚逐渐减轻或恢复正常，心肌收缩蛋白Ｃａ￣（２＋），Ｍｇ￣（２＋）－ＡＴＰ酶活性也逐渐升高。因此说明：心肌收缩蛋白Ｃａ￣（２＋），Ｍｇ￣（２＋）－ＡＴＰ酶活性的改变是心功能变化的重要生化基础之一，它的减低是缺氧心肌对环境的代偿适应。
The rats were placed in hypoxia for 1 week in a hypobaric chamber simulated altitude of 8km and for 1 week and 2 weeks after anoxia in the air. The left and right ventricular function, cardiac hypertrophy, myocardial contractile protein content and Ca ~ (2+) ), Mg ~ (2 +) - ATPase activity of the dynamic changes. The results showed that pulmonary arterial pressure and right ventricular systolic pressure increased significantly after 1km of 8km hypoxia, and the ± dp / dtmax and systolic index of left and right ventricles were significantly decreased. Left and right ventricular hypertrophy, myocardial contractile protein Ca ~ (2 +), Mg ~ (2 +) - ATPase activity was significantly reduced. After hypoxia and hypoxia for 1 and 2 weeks, the left and right ventricular function gradually recovered to or near normal levels, myocardial hypertrophy gradually reduced or returned to normal, myocardial contractile protein Ca ~ (2 +), Mg ~ (2 +) - ATPase activity Gradually increased. Therefore, the changes of myocardial contractile protein Ca ~ (2 +), Mg ~ (2 +) - ATPase activity is one of the important biochemical basis of cardiac function changes, and its reduction is the compensatory adaptation of the hypoxic myocardium to the environment.