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乙炔睾酮的甾体类似物丹那唑作为避孕药已在小鼠、沙土鼠、大鼠、家兔以及男人身上作过试验,也研究了其作用机理,发现丹那唑可抑制精子发生,但也使性欲减退。作者发现,丹那唑与睾酮庚酸酯(TE)合并使用,可使100%的动物发生无精子或严重的精子缺乏,而性欲并不减退。在家兔中此作用完全可逆。15个近亲繁殖的同一年龄组(8～9个月)的新西兰雄性白兔(1.4～1.6kg),每笼一个养在通风良好的房间内,每天口服剂量为15mg/kg 体
Danazol, a steroidal analog of testosterone, has been tested in mice, gerbils, rats, rabbits and men as contraceptives, and its mechanism of action has also been investigated and found that it inhibits spermatogenesis but also causes Loss of libido. The authors found that, in combination with testosterone heptanoate (TE), danazol can cause azoospermia or severe sperm deficiency in 100% of animals without loss of libido. In rabbits this effect is completely reversible. Fifteen New Zealand white male rabbits (1.4-1.6 kg) of the same inbreeding age group (8-9 months) were housed in a well-ventilated room with a daily oral dose of 15 mg / kg body