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目的:考察抗感染药应用与细菌耐药的相关性。方法:采用回顾性调查分析方法,以抗感染药消耗金额、使用频度变化趋势及临床标本中分离的细菌药敏试验结果为评价指标,对我院2005～2007年抗感染药应用与细菌耐药情况的相关性进行分类统计、综合分析。结果:3年来抗感染药消耗金额呈现出逐年增长趋势,住院病人抗感染药使用百分率分别为53.0%,59.0%,71.4%。其他β-内酰胺类、头孢菌素类、β-内酰胺酶抑制药、抗真菌药占整个抗感染药消耗金额的60%以上,使用频度也位居前列。临床标本检出的优势菌群随年度的变化而发生较大的排序位移,位居前9位的优势菌对常用抗菌药的耐药率逐年提高。结论:细菌耐药与抗感染药的过度应用有关。
Objective: To investigate the correlation between anti-infectives and bacterial resistance. Methods: A retrospective investigation and analysis method was used to evaluate the anti-infective drug resistance and bacterial resistance in our hospital from 2005 to 2007 based on the consumption amount of anti-infective drug, the changing trend of frequency of use and the bacterial susceptibility test results isolated from clinical samples Drugs related to the classification statistics, a comprehensive analysis. Results: The consumption of anti-infectives showed a trend of increasing year by year. The percentage of anti-infectives used in inpatients was 53.0%, 59.0% and 71.4% respectively. Other β-lactams, cephalosporins, β-lactamase inhibitors, antifungal drugs account for more than 60% of the total consumption of anti-infective drugs, the frequency of use is also among the forefront. The dominant colonies detected by clinical specimens changed greatly with the annual change, and the top 9 strains of dominant bacteria showed an increasing rate of resistance to common antibacterials year by year. Conclusions: Bacterial resistance is associated with overuse of anti-infectives.