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目的调查医院假丝酵母菌性阴道炎患者病原性真菌的菌种分布特点及耐药现状,为临床治疗真菌感染选择药物提供参考依据。方法严格按照《全国临床检验操作规程》,采用常规方法分离、鉴定假丝酵母菌属;采用K-B法进行药物敏感试验。结果从197例假丝酵母菌性阴道炎患者的阴道分泌物中检出5种假丝酵母菌,其中白色假丝酵母菌居首位,占75.1%,其次为热带假丝酵母菌,占9.1%,近平滑假丝酵母菌占5.6%,光滑假丝酵母菌和克柔假丝酵母菌均占5.1%;5种假丝酵母菌对两性霉素B、制霉菌素敏感率均为100.0%,对氟康唑、克霉唑、伊曲康唑等常用抗真菌药物的耐药率为5.4%~22.3%。结论假丝酵母菌性阴道炎的病原真菌已产生了不同程度的耐药性,应重视假丝酵母菌培养和药敏试验,指导临床合理选择抗真菌药物。
Objective To investigate the distribution characteristics and drug resistance of pathogenic fungi in patients with Candida vaginitis and to provide a reference for clinical treatment of fungal infections. Methods Strictly in accordance with the “National Clinical Laboratory Procedures”, using conventional methods to separate and identify Candida; using K-B method for drug sensitivity test. Results Candida candida was detected in vaginal secretions of 197 Candida vaginitis patients, of which Candida albicans was the first, accounting for 75.1%, followed by Candida tropicalis, accounting for 9.1% , Candida parapsilosis accounted for 5.6%, Candida glabrata and Candida krusei accounted for 5.1%, 5 Candida albicans B, nystatin sensitive rate was 100.0% Resistance rates to fluconazole, clotrimazole, itraconazole and other commonly used antifungal agents ranged from 5.4% to 22.3%. Conclusion Candida vaginitis pathogenic fungi have produced different degrees of drug resistance, should pay attention to the culture of Candida and drug susceptibility tests to guide the clinical rational choice of antifungal agents.