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目的观察组胺受体拮抗剂治疗儿童支原体肺炎的疗效。方法 96例支原体肺炎患儿随机分两组,对照组48例采用常规阿奇霉素综合治疗,治疗组在阿奇霉素综合治疗基础上加服抗组胺药物地氯雷他定,观察临床效果。结果治疗组患儿发热缓解时间,肺部啰音消失时间,咳嗽消失时间明显短于对照组(P<0.01)。血清总IgE水平治疗组治疗前后比较差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05)。血清总IgE水平,两组患儿治疗后比较差异有统计学意义(P<0.01)。结论抗组胺类药物能减轻和抑制机体的炎症反应,辅助治疗支原体感染肺炎有效,值得临床推广。
Objective To observe the curative effect of histamine receptor antagonist on mycoplasma pneumonia in children. Methods 96 cases of children with mycoplasma pneumonia were randomly divided into two groups. The control group of 48 cases were treated with conventional azithromycin. The treatment group was given desloratadine, an antihistamine, on the basis of azithromycin treatment, and the clinical effect was observed. Results The treatment group, fever relief time, pulmonary rales disappear time, cough disappeared significantly shorter than the control group (P <0.01). Serum total IgE levels before and after treatment in the treatment group was significantly different (P <0.05), before and after treatment in the control group was no significant difference (P> 0.05). Serum total IgE levels, two groups of children after treatment, the difference was statistically significant (P <0.01). Conclusion Antihistamines can reduce and inhibit the body’s inflammatory response, adjuvant treatment of mycoplasma pneumonia is effective, worthy of clinical promotion.