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目的 探讨UBIO治疗急性脑梗死的可能机制。方法 将 5 8例急性脑梗死随机分成两组 ,U BIO治疗组和常规治疗组 ,在治疗前、治疗后第 1天、第 7天、疗程结束后 (第 14天 )动态观察两组脑梗死患者红细胞膜K+ Na+ ATPase和Ca2 + Mg2 + ATPase活力的变化。结果 UBIO治疗组患者红细胞膜K+ Na+ATPase和Ca2 + Mg2 + ATPase的活力在治疗后很快增加 ,并在治疗期间持续增高 ,与治疗前相比具有显著或非常显著差异 ,而常规治疗组在治疗期间无变化。结论 UBIO对急性脑梗死患者的疗效机理可能是通过增加红细胞膜K+ Na+ ATPase和Ca2 + Mg2 + ATPase活力来增强患者红细胞变形能力 ,降低红细胞聚集性 ,从而改善患者高粘血症状态。
Objective To investigate the possible mechanism of UBIO in the treatment of acute cerebral infarction. Methods Fifty-eight acute cerebral infarction patients were randomly divided into two groups: UBIO treatment group and conventional treatment group. Before treatment, on the first day, on the seventh day after treatment, after the end of the treatment (on the fourteenth day), cerebral infarction Changes of erythrocyte membrane K + Na + ATPase and Ca2 + Mg2 + ATPase activity in patients. Results The activities of erythrocyte membrane K + Na + ATPase and Ca2 + Mg2 + ATPase in UBIO treatment group increased rapidly after treatment and continued to increase during the treatment, with significant or very significant difference compared with that before treatment, while those in the conventional treatment group No change during treatment. Conclusion The mechanism of action of UBIO in patients with acute cerebral infarction may be to improve erythrocyte deformability, reduce erythrocyte aggregation, and improve hyperviscosity in patients by increasing the activity of K + Na + ATPase and Ca2 + Mg2 + ATPase in erythrocyte membrane.