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目的研究地塞米松对PRK术后角膜修复的影响及其作用机理。方法对15只新西兰白兔双眼行准分子激光角膜切削术，术后右眼给予地塞米松，左眼为对照。术后分别进行裂隙灯、光镜和透射电镜检查。结果术后4、8wk，地塞米松组角膜Haze轻于对照组，两组间角膜上皮厚度和角膜基质细胞数无显著性差异（P＞0．05）。结论地塞米松通过减少细胞外基质的合成而减轻Haze的形成，对角膜上皮细胞和角膜基质细胞的增生无影响。
Objective To study the effect of dexamethasone on corneal repair after PRK and its mechanism. Methods Fifteen New Zealand white rabbits underwent excimer laser keratectomy. Dexamethasone was given to the right eye and left eye was used as the control. Postoperative slit lamp, light microscopy and transmission electron microscopy. Results At 4 and 8 weeks after operation, corneal Haze in dexamethasone group was lighter than that in control group. There was no significant difference in corneal epithelial thickness and corneal stromal cell number between the two groups (P> 0.05). Conclusion Dexamethasone can reduce the formation of Haze by reducing the synthesis of extracellular matrix, and have no effect on the proliferation of corneal epithelial cells and corneal stromal cells.