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胆道结石,尤其是胆固醇结石的病因已较明了。一般认为,是由于胆汁内胆固醇的过饱和,胆汁酸和卵磷脂的相对减少,破坏了胆汁内脂质的微胶粒的稳定状态,以致胆固醇发生沉淀逐渐形成结石。溶石疗法就是人们根据胆结石的形成机理给患者使用某些药物使结石溶解,达到治愈的目的。近年来国内外应用鹅脱氧胆酸等一系列药物治疗胆石,取得了良好的效果。一、鹅脱氧胆酸:1.作用机理:鹅脱氧胆酸(Chenodeoxycholicacid简称CDCA)能增大胆汁库,提高胆汁中胆汁酸浓度,抑制在肝脏内合成胆固醇的3-羟-3-甲基戊二酰辅酶A(3-hydroxy-3-methyl
The cause of biliary stones, especially cholesterol stones, has become clearer. It is generally believed that due to the supersaturation of cholesterol in the bile, the relative reduction of bile acids and lecithin disrupts the steady state of the lipid micelles within the bile, resulting in the gradual formation of stones by the precipitation of cholesterol. Soluble stone therapy is that people use some drugs to make the stones dissolve according to the formation mechanism of gallstones to achieve the purpose of healing. In recent years, domestic and international application of chenodeoxycholic acid and a series of drug treatment of gallstone, and achieved good results. First, chenodeoxycholic acid: 1. Mechanism of action: chenodeoxycholic acid (CDCA) can increase the bile pool, increase bile acid concentration, inhibit the synthesis of cholesterol in the liver of 3-hydroxy-3-methylpentane Diacyl-CoA (3-hydroxy-3-methyl