我们以前的工作业已证明,消炎痛预处理能使大鼠对CCl_4、半乳糖胺等肝毒剂的损伤产生抵抗。曾有个别报道指出,消炎痛可引起人或动物的肝功能试验异常,如果消炎痛可以损伤肝脏,那么我们所观察到的保护作用应考虑为适应性保护的现象。由于缺乏详细可靠的实验资料.本工作采用生物化学、形态学方法在整体动物和原代培养的肝细胞对消炎痛能否损伤肝脏进行了系统观察的。 Our previous work has shown that indomethacin pretreatment can make rats resistant to hepatotoxic agents such as CCl 4, galactosamine and the like. There have been several reports that indomethacin can cause abnormal liver function tests in humans or animals. If indomethacin can damage the liver, the protective effect we observe should be considered as an adaptive protection. Due to the lack of detailed and reliable experimental data, we used biochemistry and morphological methods to systematically observe whether the indomethacin can damage the liver in whole animals and primary cultured hepatocytes.