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一、引言垂体性腺轴的启动来自中枢神经系统,促使GnRH脉冲性地分泌到垂体门脉,从而影响垂体的促性腺细胞。阻断或损伤恒河猴下丘脑中央隆起弓状核,垂体促性腺激素分泌停止,性腺功能也受到抑制。Knobil及其同事首先证实了GnRH的脉冲信号的间断性。损伤下丘脑,使内生GnRH消失,代之以脉冲性而非连续性的GnRH灌注,可使LH、FSH分泌重新恢复。本文将用GnRH脉冲源(GnRH pulse generator)这一术语来阐述有关问题。GnRH脉冲源似乎是整合了神经的、激素的、也许还有代谢的信息,以影响促性腺激素分泌,从而影响性腺分泌。如青春期前,吸吮乳头引起的哺乳性闭经及节食期间GnRH脉冲性分泌受到抑制。此外,GnRH脉冲源也是性腺激素行使其对促性
I. INTRODUCTION The onset of the pituitary gonadal axis originates from the central nervous system, prompting the secretion of GnRH to the pituitary portal vein impulsively, thereby affecting pituitary gonadal cells. Block or damage the rhesus monkey hypothalamic central arcuate nucleus, pituitary gonadotropin secretion stopped, gonadal function is also inhibited. Knobil and colleagues first confirmed the discontinuity of the pulse signal of GnRH. Damage to the hypothalamus, endogenous GnRH disappeared, replaced by a pulsed rather than continuous GnRH perfusion, LH, FSH secretion can be restored. This article will use the GnRH pulse generator (GnRH pulse generator) term to explain the issue. GnRH pulse sources seem to be integrated nerves, hormones, and perhaps metabolic messages that affect gonadotropin secretion and thus gonadal secretion. As before puberty, sucking nipples caused by lactating amenorrhea and dietary GnRH pulse secretion was inhibited. In addition, GnRH pulsatile sources also act as gonadal hormones to promote sexuality