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目的:研究B型利钠肽(BNP)水平对慢性心力衰竭(CHF)患者预后的影响。方法:选取2012年5月~2015年5月之间于我院接受治疗的CHF患者150例,根据根据心功能分级标准分为三组,每组各50例,比较各组的左室射血分数(LVEF)、左心室舒张末内径(LVEDD)、血浆BNP水平,对患者进行为期2年的随访,统计其BNP水平升高情况,比较升高者与正常者的预后情况。结果:与血浆BNP水平正常者相比,血浆BNP水平升高者的年平均住院时间更长、年平均住院次数更多、死亡率更高,P<0.05。结论:CHF患者的心功能可以通过血浆BNP水平反映出来,BNP水平升高,说明预后效果较差,风险较高,BNP能够被用于评价心衰患者的治疗与预后效果。
Objective: To study the effect of B-type natriuretic peptide (BNP) on the prognosis of patients with chronic heart failure (CHF). Methods: One hundred and fifty patients with CHF who were treated in our hospital from May 2012 to May 2015 were divided into three groups according to the classification of cardiac function, 50 cases in each group. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and plasma BNP levels. Patients were followed up for 2 years. The level of BNP was measured and the prognosis was compared between elevated and normal subjects. Results: Compared with patients with normal plasma BNP, those with higher plasma BNP levels had longer average length of stay, more annual hospitalizations, and higher death rates (P <0.05). CONCLUSIONS: The cardiac function in patients with CHF can be reflected by the plasma BNP level and the BNP level is elevated, indicating that the prognosis is poor and the risk is high. BNP can be used to evaluate the treatment and prognosis of patients with CHF.