论文部分内容阅读
本实验应用健康日本大耳白家兔26只,随机分为治疗及对照两组;全部动物以高脂血症附加免疫损伤诱发动脉粥样硬化。实验期间治疗组按3个疗程静脉注射PGE_1,对照组不给药。采用组织学观察、血小板机能试验、环核苷酸测定、循环免疫复合物检查、血脂测定及血清脂蛋白电泳等一系列形态与功能指标。12周后解剖,计数测量主动脉脂质斑块面积,结果均值对照组为33.3±7.6％,治疗组仅7.4±3.7％,P<0.01,证实体内注射PGE_1能够有效地抑制主动脉脂质斑块的形成。实验中还观察到:①PGE_1可有效地
In this experiment, 26 healthy Japanese white rabbits were randomly divided into treatment and control groups; All animals were induced atherosclerosis by additional immunodamage with hyperlipidemia. During the experimental period, the treatment group received intravenous injection of PGE 1 for 3 courses and no control group. Histological observations, platelet function tests, cyclic nucleotide assays, circulating immune complex tests, blood lipid assays, and serum lipoprotein electrophoresis were used for a series of morphological and functional parameters. After 12 weeks of dissection, the atherosclerotic plaque area was counted. The mean value of the control group was 33.3±7.6%, and the treatment group was only 7.4±3.7%, P<0.01. Intravitreal injection of PGE_1 could effectively inhibit aortic plaques. Block formation. Also observed in the experiment: 1PGE_1 can effectively