对25例过敏性肺炎患者和4例对照者支气管肺泡灌洗液(BALF)中的胶原酶及其活性、非金属蛋白酶抑制酶进行了评估。全部患者用强的松治疗,并追踪观察2～3年,根据疗效将患者分成3组:治愈组、好转组、恶化组。检测结果:对照组的 BALF 中无免疫反应性胶原酶。但患者组胶原酶阳性者:治愈组4例(4/7)、好转组6例(6/10)、恶化组4例(4/8)。结果说明 BALF 中胶原酶是否存在、浓度 Collagenase and its activity, and non-metalloproteinase-inhibiting enzyme in bronchoalveolar lavage fluid (BALF) from 25 patients with allergic pneumonia and 4 controls were evaluated. All patients were treated with prednisone, and follow-up observation of 2 to 3 years, according to the efficacy of the patients were divided into 3 groups: cured group, improved group, worsened group. Test Results: There was no immunoreactive collagenase in the BALF of the control group. However, the patients with collagenase-positive were cured in 4 cases (4/7), improved in 6 cases (6/10), and worsened in 4 cases (4/8). The results indicate the presence or absence of collagenase in BALF