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探讨不同类型白血病和不同病期白血病的血清酶活性变化，以及酶活性与外周血白细胞总数、白血病细胞数的关系。方法：采用酶联法测定75例白血病患者血清乳酸脱氢酶（LDH）、谷丙转氨酶（GPT）、碱性磷酸酶（AKP）活性，并与正常人组38例比较。结果：白血病组LDH、AKP活性明显高于正常人组，且急性淋巴细胞白血病（ALL）者的LDH活性与外周血白血病细胞数呈正相关（P＜0．01）；白血病完全缓解期（CR）患者LDH活性明显低于初发患者（P＜0．01），血清GPT活性与正常人无显著性差异（P＞0．05）。结论：动态观察血清LDH活性有助于白血病疗效的判断。
To investigate the changes of serum enzyme activity in different leukemia types and different disease stages, and the relationship between enzyme activity and the total number of white blood cells and leukemia cells in peripheral blood. METHODS: Serum lactate dehydrogenase (LDH), alanine aminotransferase (GPT) and alkaline phosphatase (AKP) activity in 75 patients with leukemia were measured by enzyme-linked immunosorbent assay (ELISA) and compared with 38 normal controls. Results: The activity of LDH and AKP in the leukemia group was significantly higher than that in the normal group. The LDH activity in acute lymphoblastic leukemia (ALL) was positively correlated with the number of leukemia cells in the peripheral blood (P<0.01); the complete remission period (CR) of leukemia The LDH activity in patients was significantly lower than that in newly diagnosed patients (P<0.01). There was no significant difference in serum GPT activity between healthy subjects and normal controls (P>0.05). Conclusion: The dynamic observation of serum LDH activity is helpful for judging the efficacy of leukemia.