现将30多年来国内外发现的疟疾少见的临床表现及其治疗原则综述于下。先天性疟疾先天性疟疾是指婴儿在母体内感染的疟疾。正常的胎盘有着完好的壁障,母体内的疟原虫不能够通过胎盘进入胎儿体内,但当胎盘发生某种病变或损伤使母体血液与胎儿血液混合等,则可引起先天性疟疾。目前,国内外已报道有300多例先天性疟疾。患儿多在出生后3～5周发病,少数在1周时即出现病态。临床表现不典型,常有 The rare clinical manifestations and treatment principles of malaria found in the past 30 years are summarized below. Congenital malaria Congenital malaria refers to malaria in infants infected in the mother’s body. The normal placenta has intact barriers, malaria parasites within the mother can not enter the fetus through the placenta, but when placenta lesions or damage to the maternal blood and fetal blood mixed, can cause congenital malaria. At present, more than 300 cases of congenital malaria have been reported both at home and abroad. Children more than 3 to 5 weeks after onset of disease, a few appear in 1 week pathological. Clinical manifestations are not typical, often