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以饮用高氟水的方法制造了雌性小白鼠慢性氟中毒模型。观察了氟中毒授乳小白鼠所哺育的仔鼠生长情况,以荧光分光光度法测定了氟中毒授乳小白鼠脑组织5—羟色胺(5—HT),5—羟吲哚乙酸(5—HIAA)和多巴胺(DA)的含量。结果不论仔鼠是否由对照组或实验组母鼠所生,只要其生后由对照组授乳鼠来哺育,则其体重增长情况正常;不论仔鼠是否由对照组或实验组所生,只要其生后由实验组授乳鼠来哺育,则其体重增长则显著落后。上述结果揭示:(1)慢性氟中毒可抑制小白鼠泌乳功能;(2)慢性氟中毒授乳小白鼠脑组织5—羟色胺和5—羟吲哚乙酸有降低趋势,而多巴胺则有升高趋势。—羟色胺和5—羟吲哚乙酸有降低趋势,而多巴胺则有升高趋势。
Chronic fluorosis model of female mice was made by drinking high fluoride water. The growth of offspring fed with fluoride poisoning lactating mice was observed. The contents of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) Dopamine (DA) content. Results Regardless of whether the offspring born by the control group or the experimental group of mothers, as long as their birth by the control group of suckling mice to nurture, then the weight gain is normal; whether the offspring by the control group or experimental group, as long as the After birth by the experimental group of suckling mice to nurture, then the weight gain was significantly behind. The above results revealed that: (1) Chronic fluorosis can inhibit the lactation function in mice; (2) Serum 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the mice with chronic fluorosis showed decreased tendency, while the dopamine increased. - serotonin and 5 - hydroxyindole acetic acid have a downward trend, while there is an upward trend of dopamine.