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目的：探讨纤维连接蛋白（Ｆｎ）在正常膀胱及膀胱癌组织中的分布情况。方法：应用免疫组化技术对５例正常膀胱组织，３３例膀胱癌组织中的Ｆｎ分布进行了观察。结果：发现正常膀胱组织中Ｆｎ分布于基膜及粘膜下组织，上皮层无Ｆｎ。而膀胱癌组织中基膜 Ｆｎ有不同程度的丧失，Ｆｎ表达阴性或弱阳性为 ６３．６％（２１／３３）。浸润性癌及分化差的膀胱癌组织中 Ｆｎ丧失明显， １２例浸润性膀胱癌中，１０例 Ｆｎ表达阴性或弱阳性为 ８３．３％（１０／１２）。 １３例有复发转移的患者，Ｆｎ表达阴性或弱阳性的为 １０例（７６．９％）。结论：作为细胞外基质主要成分的Ｆｎ在膀胱癌中均有不同程度的丧失，且Ｆｎ丧失越多，膀胱癌浸润程度越高，越容易复发转换。
Objective: To investigate the distribution of fibronectin (Fn) in normal bladder and bladder cancer tissues. Methods: The distribution of Fn in 5 cases of normal bladder tissue and 33 cases of bladder cancer was observed by immunohistochemistry. Results: Fn in normal bladder tissue was found in basilar membrane and submucosal tissue without Fn. However, the Fn in the bladder cancer tissue had a certain degree of loss, with a negative or weak Fn expression of 63.6% (21/33). In invasive carcinoma and poorly differentiated bladder cancer, the loss of Fn was significant. In 12 invasive carcinoma of the bladder, the positive or negative expression of Fn in 10 cases was 83.3% (10/12). Thirteen patients had recurrence and metastasis, Fn negative or weakly positive in 10 cases (76.9%). CONCLUSION: Fn, which is the main component of extracellular matrix, has different degrees of loss in bladder cancer, and the more Fn loss, the higher the degree of infiltration of bladder cancer, the more easily recurrence and transformation.