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目的 :探讨 3类常用抗高血压药物对非杓型的高血压病患者BP的时间生物学特征的影响。方法 :共入选非杓型BP分布的高血压病患者 16 1例 ,将其随机分为 3组 ,分别给予赖诺普利 (10mg·d-1) ,非洛地平 (2 5mg·d-1) ,或氢氯噻嗪 (5 0mg·d-1) ,并于治疗前后行 2 4h动态BP监测。采用余弦拟合方法分析治疗前后患者BP时间生物学特征的改变。结果 :赖诺普利组与非洛地平组治疗后 2 4hBP均值明显降低 ,但其振幅、峰值相位无变化 ;氢氯噻嗪治疗降压效果不甚理想 ,但显著增加了患者BP的夜间降低幅度 ,使患者BP由非杓型转变为杓型分布。结论 :氢氯噻嗪治疗可能使非杓型分布的高血压病患者的BP转变为杓型分布 ,从而有助于降低患者相关并发症的发生率。
Objective: To investigate the effects of three common antihypertensive drugs on the temporal biology of BP in non-dipper hypertensive patients. Methods: Totally 161 hypertensive patients with non-dipper BP were enrolled in this study. They were randomly divided into 3 groups: lisinopril (10 mg · d-1), felodipine (25 mg · d-1 ), Or hydrochlorothiazide (50 mg · d-1), and monitored by dynamic BP 24 hours before and after treatment. Cosine fitting method was used to analyze the changes of biological characteristics of BP in patients before and after treatment. Results: The mean of 24 hBP decreased significantly in lisinopril and felodipine groups, but the amplitude and peak phase did not change. Hydrochlorothiazide was less effective in lowering blood pressure, but significantly increased the nighttime decrease of BP BP patients from non-dipper into dipper distribution. Conclusions: Hydrochlorothiazide treatment may result in the conversion of BP in non-dipper hypertensive patients into a dipper, thereby contributing to a reduction in the incidence of patient-related complications.