目的：考察我国青霉素口服制剂免做皮试的安全性。方法：所有患者在医护人员督导下免做皮试口服青霉素Ｖ。结果：１００４５例患者中出现不良反应与药物有关者２３４例（２．３３％），很可能有关者５３例（０．５３％），不良反应发生率为２．８６％（２８７例）。结论：在服药前详细询问过敏史的前提下，免做青霉素皮试用于临床基本是安全的 Objective: To investigate the safety of penicillin oral preparation in China. Methods: All patients under the supervision of medical staff without skin test oral penicillin V. Results: Among 10045 patients, 234 (2.33%) were adverse drug reactions, and most likely related to 53 patients (0.53%), the adverse reaction rate was 2.86% (287 patients). Conclusion: Before taking the detailed history of allergy asked under the premise of non-penicillin skin test for clinical use is basically safe