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目的评价山东省健康人群风疹抗体水平。方法 2009年和2010年共选取山东省12个设区的市,各市按照分层随机原则选取<2岁~≥40岁共8个年龄组的健康人群作为观察对象,并采集血清标本,用酶联免疫吸附试验单孔定量方法检测风疹免疫球蛋白(Immunoglobulin,Ig)G,并进行统计分析。结果 2009、2010年12个市共检测健康人群血清标本4001份,风疹抗体阳性率为83.13%、抗体几何平均浓度(Geometric Mean Concentration,GMC)为40.42国际单位/毫升(IU/ml)。2010年明显高于2009年。不同地区和不同年龄组人群风疹抗体阳性率及GMC差异均有统计学意义(χ2=81.254,P<0.01;F=8.55,P<0.05;χ2=44.273,P<0.01;F=3.68,P<0.05),不同性别人群差异均无统计学意义(χ2=0.100,P>0.05;F=28.63,P>0.05)。≤10岁儿童风疹抗体阳性率较低,其中<2岁、5~7岁儿童阳性率<80%。抗体阳性率随年龄增长升高趋势明显,但抗体GMC总体呈降低趋势,尤以≥20岁成人更为明显。结论加强儿童麻疹-风疹联合减毒活疫苗(Measles and Rubella Combined Attenuated Live Vaccine,MR)的常规免疫接种,控制风疹流行;同时应关注育龄期妇女MR的预防接种,预防先天性风疹综合征。
Objective To evaluate the level of rubella antibody in healthy population in Shandong Province. Methods A total of 12 cities in Shandong Province were selected in 2009 and 2010, and cities were selected according to the stratified randomization principle. Healthy people of 8 age groups <2 years old to 40 years old were selected as the observation subjects, and serum samples were collected. Immunoadsorption assay was used to detect rubella immunoglobulin (Ig) G by single-well quantitative assay and statistical analysis was performed. Results In 2009 and 2010, there were 4001 serum samples from 12 healthy people. The positive rate of rubella antibody was 83.13%. The Geometric Mean Concentration (GMC) was 40.42 IU / ml. 2010 was significantly higher than in 2009. The positive rate of rubella antibody and GMC in different regions and different age groups were statistically significant (χ2 = 81.254, P <0.01; F = 8.55, P <0.05; χ2 = 44.273, P <0.01; F = 3.68, P < 0.05). There was no significant difference among different sex groups (χ2 = 0.100, P> 0.05; F = 28.63, P> 0.05). Less than 10 years old children rubella antibody positive rate, of which <2 years old, 5-7 years old children positive rate <80%. The positive rate of antibody increased with age significantly, but the antibody GMC generally showed a decreasing trend, especially in adults ≥ 20 years old. Conclusion The routine immunization of Measles and Rubella Combined Attenuated Live Vaccine (MR) vaccine should be strengthened to control the epidemic of rubella. At the same time, MR vaccination should be focused on women of childbearing age to prevent congenital rubella syndrome.