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根据天然海藻糖酶抑制剂的结构设计了一类吡啶甲基亚氨基噻 ( )唑烷化合物 ,通过吡啶甲基异硫氰酸酯和相应的胺反应 ,然后在盐酸或黄色氧化汞条件下关环 ,合成了吡啶甲基亚氨基噻唑烷和唑烷 ,其结构得到 IR、1H NMR、HRMS的确证。测试了化合物对昆虫 (家蝇 )飞行的抑制能力。对影响合成反应的因素以及生测结果进行了讨论
According to the structure of the natural trehalase inhibitor, a class of picolylimidazolium (oxazolidine) compounds were designed and synthesized by the reaction of picolyl isothiocyanate with the corresponding amines and then with hydrochloric acid or yellow mercuric oxide Ring closure, the synthesis of a picolyl methyl iminothiazolidine and oxazolidine, its structure has been confirmed by IR, 1H NMR, HRMS. Compounds were tested for their ability to inhibit flight of insects (houseflies). The factors affecting the synthesis reaction and the results of biochemical tests are discussed