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糖皮质激素应用于临床,往往忽视副作用,造成不良后果,现将应注意的几个问题介绍如下:1 感染性疾病:(1)感染严重时可考虑采用激素。(2)心血管病:主要用于抢救休克,而且仅在感染性休克及过敏性休克时,激素方有较好疗效。(3)消化系统疾病:主要用于肝、肠炎与自身免疫性疾病。(4)皮肤病:用于严重的药物性皮炎,如大疱表皮松懈症和萎缩性药疹,用量宜大。(5)变态反应性疾病:亦仅用于严重过敏性反应,如抢救过敏性休克,严重药物皮炎,哮喘持续状态,输血过敏反应,自身免痊性血液病中如溶血性贫血危象。(6)造血系统疾病和恶性肿瘤:这些疾病中激素与抗癌剂结合应用非常广泛。(7)代谢性疾病:主要作为替代补充分泌不足或利用其抗过敏反馈抑制或糖原异生作用等。2 禁忌证: (1)严重精神病;(2)活动性消化性溃
Glucocorticoids used in clinical, often neglect side effects, resulting in adverse consequences, will now pay attention to several issues described below: 1 infectious diseases: (1) serious infection may consider the use of hormones. (2) cardiovascular disease: mainly used to rescue shock, and only in septic shock and anaphylactic shock, hormone side has a good effect. (3) digestive diseases: mainly for liver, enteritis and autoimmune diseases. (4) Dermatology: For serious drug dermatitis, such as epidermolysis bullosa and atrophic drug eruption, dosage should be large. (5) allergic diseases: also only for severe allergic reactions, such as salvage anaphylactic shock, severe drug dermatitis, asthma persistence, transfusion allergy, autoimmune hematological diseases such as hemolytic anemia crisis. (6) Hematopoietic system diseases and malignant tumors: The combination of hormones and anticancer agents in these diseases is widely used. (7) Metabolic diseases: mainly as an alternative to supplement the lack of secretion or the use of its anti-allergic feedback inhibition or glycogen isoforms and so on. 2 contraindications: (1) severe mental illness; (2) active digestive collapse