论文部分内容阅读
目的:观察腹部火器伤肠管穿透后心肌损伤的变化。方法:健康长白仔猪42头随机分为对照组以及伤后1h、2h、4h、8h、12h和24h组。实验组建立腹部火器伤肠管穿透模型后,分别测定伤后1 h、2h、4h、8h、12h和24h组各组动物血清中LDH、CK、CK-MB水平,并与对照组比较,观察实验组各时间点心脏组织学变化?结果:伤后各组血清LDH、CK、CK-MB水平均高于对照组。伤后8h、12h、24h组光镜下出现逐渐加重的心肌细胞水肿、变性;电镜下4h、8h、12h、24h组出现逐渐的线粒体肿胀、溶解;对照组光、电镜下未见明显的损伤性变化。结论:腹部火器伤肠管穿透导致心肌形态和酶的损伤性变化,随着伤后时间的延长而加重。
Objective: To observe the changes of myocardial injury after intestine firearm wound. Methods: Forty-two healthy white piglets were randomly divided into control group and 1h, 2h, 4h, 8h, 12h and 24h after injury. The experimental group established the model of intestine peritoneal firearm wounds and then determined the serum levels of LDH, CK and CK-MB in the groups of 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after injury respectively and compared with the control group Histological changes in the experimental group at each time point? Results: Serum levels of LDH, CK, CK-MB in the post-injury groups were higher than those in the control group. At 8h, 12h and 24h after injury, the progressive edema and degeneration of cardiomyocytes were observed in the light microscope. Gradual mitochondrial swelling and lysis were observed at 4h, 8h, 12h and 24h after electron microscopy. In the control group, no obvious damage was found under light and electron microscopy Sexual change. CONCLUSIONS: Intestinal tracheal penetration of firearm wounds in the abdomen leads to changes in myocardial morphology and enzyme damage, which aggravates with prolonged injury time.