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在慢性和急性缺氧条件下，Ｈｉｌｌｔｏｐ（ＨＴ）大鼠肺血管阻力（ＰＶＲ）升高程度显著比Ｗｉｓｔａｒ（ＷＴ）大鼠高。吲哚美辛可减少ＷＴ大鼠ＰＧＩ＿２产生，提高ＰＶＲ；对ＨＴ大鼠则减少ＴＸＡ＿２产生，降低ＰＶＲ。乙胺嗪和Ｕ－６０２５７Ｂ通过抑制５－脂加氧酶使白三烯（ＬＴｓ）产生减少，在缓解两种大鼠的缺氧性ＰＶＲ增高中起重要作用。
Hilltop (HT) rats had significantly higher pulmonary vascular resistance (PVR) than Wistar (WT) rats under chronic and acute hypoxia conditions. Indomethacin can reduce PGI 2 production and PVR in WT rats, reduce TXA 2 production and decrease PVR in HT rats. Both diethylcarbamazine and U-60257B play an important role in alleviating the hypoxic PVR increase in both rats by inhibiting the production of leukotrienes (LTs) by inhibiting 5-lipoxygenase.