论文部分内容阅读
器官纤维化的发生与细胞外基质(ECM)的过度沉积有关。过去认为组织固有(肌)成纤维细胞是细胞外基质生成的主要细胞,近年来的研究则发现,血液中骨髓来源的循环纤维细胞在纤维化疾病的产生和发展过程起到了重要的作用。活化的循环纤维细胞不仅自身可分泌细胞外基质参与纤维化进程,也能通过分化成为(肌)成纤维细胞来发挥生理性和病理性的纤维化作用。循环纤维细胞具有多种生物学功能,能直接分泌各种细胞因子或促进相关因子的生成来促进纤维化进程。同时,循环纤维细胞的生成、转移、分化及其致纤维化作用也受到了不同的细胞因子和信号通路的调控。我们主要对于近年来循环纤维细胞与器官纤维化的研究进展予以综述。
The occurrence of organ fibrosis is associated with excessive deposition of extracellular matrix (ECM). In the past, tissue-specific (myofibrillar) fibroblasts were thought to be the major extracellular matrix-forming cells. In recent years, studies have found that bone marrow-derived circulating fibroblasts in the blood play an important role in the generation and development of fibrotic diseases. Activated circulating fibroblasts not only can themselves secrete extracellular matrix involved in the process of fibrosis, but also through the differentiation into (muscle) fibroblasts to play a physiological and pathological fibrosis. Circulating fibroblasts have a variety of biological functions, can directly secrete a variety of cytokines or promote the formation of related factors to promote fibrosis. At the same time, the generation, metastasis, differentiation of fibroblasts and their fibrogenic effects are also regulated by different cytokines and signaling pathways. We mainly summarize the research progress of circulating fibrocytes and organ fibrosis in recent years.