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某些非阿司匹林非类固醇抗炎药(NSAID)对胃的副作用虽已得到重视,但对这些药物的其它可能副作用则尚注意得较少。作者在美国北卡罗来纳州进行一项有关慢性肾脏疾病危险因素的多中心病例对照研究,作为这项研究工作的一部分,评价了慢性肾脏疾病与定期应用 NSAID 的关系。病人和方法 554例病人为北卡罗来纳州居民,年龄30～79岁,于1980～1982年住医院,出院诊断为慢性肾功能不全,血清肌酐水平恒处于≥130μmol/L(1.5mg/dL)。对照组共516人,其中一部分在65岁以内,系通过电话号码随机选出,另一部分年龄≥65岁,系通过参加医疗保险的名单选
Although some non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) have been noted for their side effects on the stomach, other possible side effects of these drugs are less often noted. In a multicenter case-control study of risk factors for chronic kidney disease in North Carolina, USA, the authors evaluated the relationship between chronic kidney disease and the regular use of NSAID as part of the study. Patients and Methods 554 patients were residents of North Carolina aged 30-79 years. They lived in hospitals from 1980 to 1982 and were discharged as chronic renal insufficiency with serum creatinine levels ≥130 μmol / L (1.5 mg / dL). A total of 516 control subjects, some of which are within 65 years of age, are randomly selected by telephone number, the other part of the age of 65 years of age, by participating in the medical insurance list