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目的探讨消化系统恶性肿瘤合并急性脑梗死的临床特征,以提高医生对本病的认识,减少误诊率。方法 34例消化系统恶性肿瘤合并急性脑梗死患者作为肿瘤组,34例单纯性急性脑梗死患者作为非肿瘤组,收集两组临床资料并进行统计分析。结果两组患者年龄、性别比较差异无统计学意义(P>0.05)。两组高血压例数(10例VS 23例)及无危险因素例数(9例VS2例)比较差异有统计学意义(P<0.05);两组卒中史、糖尿病、心脏病、酗酒史、吸烟史例数比较差异无统计学意义(P>0.05)。两组血红蛋白(HGB)、血小板(PLT)、同型半胱氨酸(Hcy)水平比较差异具有统计学意义(P<0.05);两组血糖(BS)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(FIB)水平比较差异无统计学意义(P>0.05)。两组脑梗死灶分布比较差异具有统计学意义(P<0.05);两组脑梗死类型比较差异无统计学意义(P>0.05)。结论消化系统恶性肿瘤合并急性脑梗死与单纯性急性脑梗死发病的危险因素有所不同;合并消化系统恶性肿瘤患者HGB、PLT、TG、TC、LDL-C水平较低,常合并高同型半胱氨酸血症,病灶多为皮层梗死分布于单侧大脑半球。
Objective To investigate the clinical features of digestive system malignant neoplasm with acute cerebral infarction in order to improve the doctor’s understanding of the disease and reduce the misdiagnosis rate. Methods Twenty - four patients with malignant tumor of digestive system complicated with acute cerebral infarction were selected as tumor group and 34 patients with simple acute cerebral infarction as non - tumor group. The clinical data of two groups were collected and statistically analyzed. Results There was no significant difference in age and sex between the two groups (P> 0.05). There were significant differences between the two groups in the number of hypertension (10 cases of VS 23 cases) and no risk factors (9 cases of VS2 cases) (P <0.05); two groups of stroke history, diabetes, heart disease, alcohol abuse history, There was no significant difference in smoking history (P> 0.05). The levels of hemoglobin (HGB), platelets (PLT) and homocysteine (Hcy) in the two groups had statistical significance (P <0.05). The levels of blood glucose (BS), triglyceride (TG), total cholesterol TC, LDL-C and fibrinogen (FIB) were not significantly different (P> 0.05). There was significant difference in distribution of cerebral infarction between the two groups (P <0.05). There was no significant difference in cerebral infarction between the two groups (P> 0.05). Conclusions The risk factors of digestive system malignant neoplasm with acute cerebral infarction are different from those of simple acute cerebral infarction. HGB, PLT, TG, TC and LDL-C in patients with digestive system malignant tumor are relatively low, often associated with high homocysteine Anemia, lesions mostly cortical infarction distribution in the unilateral cerebral hemispheres.