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目的探讨急性冠脉综合征患者超敏C-反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)、脑钠肽(BNP)水平变化及其临床意义。方法选择2014年6月-2016年6月就诊的98例急性冠脉综合征(ACS)患者,其中急性心肌梗死(AMI)组患者43例,不稳定型心绞痛(UAP)组患者55例,随机选取与ACS患者相匹配的稳定型心绞痛(SAP)患者40例作为SAP组,及健康体检者50例作为对照组,检测各组对象的hs-CRP、cTnI、BNP水平,并根据ACS患者病变支数分组比较hs-CRP、cTnI、BNP水平。结果 AMI组和UAP组的hs-CRP、cTnI、BNP水平显著高于SAP组和对照组;AMI组的hs-CRP、cTnI、BNP水平显著高于UAP组;3支病变组hs-CRP、cTnI、BNP水平显著高于双支病变组、单支病变组;双支病变组hs-CRP、cTnI、BNP水平又显著高于单支病变组,上述差异均有统计学意义(P<0.05)。结论 hs-CRP、cTnI、BNP与急性冠脉综合征及其严重程度密切相关。
Objective To investigate the changes of hs-CRP, cTnI and BNP in patients with acute coronary syndrome and their clinical significance. Methods From June 2014 to June 2016, 98 patients with acute coronary syndrome (ACS) were enrolled. Among them, 43 patients were in acute myocardial infarction (AMI) group and 55 patients were in unstable angina pectoris group (UAP) Forty patients with stable angina pectoris (SAP) who were matched with ACS were selected as SAP group and 50 healthy subjects as control group. The levels of hs-CRP, cTnI and BNP in each group were determined. Number of groups compared hs-CRP, cTnI, BNP levels. Results The levels of hs-CRP, cTnI and BNP in AMI group and UAP group were significantly higher than those in SAP group and control group. The levels of hs-CRP, cTnI and BNP in AMI group were significantly higher than those in UAP group. The hs-CRP, cTnI (P <0.05). The levels of BNP and BNP in patients with double-vessel disease were significantly higher than those in patients with double-vessel disease and single vessel disease. The levels of hs-CRP, cTnI and BNP in patients with double-vessel disease were significantly higher than those with single vessel disease. Conclusion hs-CRP, cTnI and BNP are closely related to the severity of acute coronary syndrome.