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早在30～40年代,硒被认为是毒剂及致癌剂,50年代开始,硒才被看作是必需的微量元素,60年代以后,流行病学调查及动物试验逐渐证实硒有抗癌作用。在良性肝病中硒有缺乏现象。由于慢性肝炎、肝硬化和肝癌关系密切,肝癌中是否亦有低硒表现?硒是否与肝癌的发生有关,值得进一步探索。一、硒与肿瘤的发生流行病学调查:Shamberser(1969)发现美国各地饲料中硒含量与当地癌死亡率呈负相关,同时人血硒水平与癌死亡率亦呈负相关。接着,Shamberger(1971～1976)
As early as the 30s and 40s, selenium was considered as a toxicant and a carcinogen. Since the 1950s, selenium was considered as an essential trace element. Since the 1960s, epidemiological investigations and animal experiments have gradually confirmed the anti-cancer effect of selenium. Selenium deficiency in benign liver disease. Because of chronic hepatitis, liver cirrhosis and liver cancer are closely related, whether liver cancer also have low selenium performance? Selenium is associated with the occurrence of liver cancer, it is worth further exploration. Epidemiological investigation of the occurrence of selenium and tumor: Shamberser (1969) found that the dietary selenium content in the United States was negatively correlated with the local cancer mortality rate, while the blood selenium level was also negatively correlated with the cancer mortality rate. Then, Shamberger (1971-1976)