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为探讨ｍｄｒ－ １ 、ＣＤ４４ｖ 和ｎｍ２３ － Ｈ１ 基因产物蛋白与肝癌侵袭、转移预后的关系。用免疫组织化学技术检测４６ 例肝癌患者ＣＤ４４ｖ 和ｎｍ２３ － Ｈ１ 和ｍｄｒ－ １ 基因蛋白的表达。结果显示肝癌组织ｍｄｒ－ １ 、ＣＤ４４ｖ 和ｎｍ２３ － Ｈ１（６０－０８ ％ ） ，明显高于正常组织和癌旁组织（ Ｐ＜ ０－０５） ；肝癌转移组的ｍｄｒ－ １ 、ＣＤ４４ｖ 阳性表达率高于ｎｍ２３ － Ｈ１ 阳性表达率，差异显著（ Ｐ＜ ０－０５） ；肝癌非转移组的ｎｍ２３ － Ｈ１ 阳性表达率显著高于ｍｄｒ－ １ 、ＣＤ４４ｖ 阳性表达率（ Ｐ＜ ０－０５） 。肝癌转移组ｍｄｒ－ １ 、ＣＤ４４ｖ 明显高于非转移组，而ｎｍ２３ － Ｈ１ 则反之（ Ｐ＜ ０－０５） 。肝癌的侵袭、转移及预后可能与ｍｄｒ－ １ 、ＣＤ４４ｖ 和ｎｍ２３ － Ｈ１ 三种基因产物的异常表达有关。
To explore the relationship between the mdr-1, CD44v, and nm23-H1 gene product proteins and the prognosis of hepatocellular carcinoma invasion and metastasis. Immunohistochemistry was used to detect the expression of CD44v and nm23-H1 and mdr-1 gene proteins in 46 patients with hepatocellular carcinoma. The results showed that mdr-1, CD44v, and nm23-H1 (60-08%) in HCC were significantly higher than those in normal tissues and paracancerous tissues (P < 0-05). The positive rate of mdr-1 and CD44v expression in liver cancer metastasis group was high. The positive expression rate of nm23-H1 was significantly different (P < 0-05). The positive expression rate of nm23-H1 in non-metastasis group was significantly higher than that of mdr-1 and CD44v (P < 0-05). The mdr-1 and CD44v in the liver cancer metastasis group were significantly higher than those in the non-metastatic group, whereas the nm23-H1 was the opposite (P<0-05). The invasion, metastasis and prognosis of HCC may be related to the abnormal expression of three gene products: mdr-1, CD44v and nm23-H1.