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目的:探讨IL-6、IL-8、TNF-α在胎膜早破早产孕妇血清及羊水中的含量与胎膜早破早产的关系。方法:采用酶联免疫吸附法测定胎膜早破早产孕妇(早产组)20例与正常孕妇(对照组)20例血清及羊水中的IL-6、IL-8、TNF-α的含量。结果:早产组母血清及羊水中IL-6、IL-8、羊水TNF-α水平均较对照组高(P<0.05)。早产组绒毛膜羊膜炎者血清、羊水中IL-6、IL-8水平高于非绒毛膜羊膜炎者(P<0.05)。结论:孕妇血清、羊水中IL-6、IL-8水平与感染引起的早产有相关关系。
Objective: To investigate the relationship between IL-6, IL-8 and TNF-α levels in serum and amniotic fluid in premature rupture of membranes and premature rupture of membranes. Methods: The levels of IL-6, IL-8 and TNF-α in serum and amniotic fluid of 20 preterm premature rupture of membranes (preterm labor group) and 20 normal pregnant women (control group) were determined by enzyme-linked immunosorbent assay. Results: The levels of TNF-α in IL-6, IL-8 and amniotic fluid in preterm labor group were significantly higher than those in control group (P <0.05). The levels of IL-6 and IL-8 in serum and amniotic fluid of chorioamnionitis preterm group were higher than those of non-chorioamnionitis (P <0.05). Conclusion: The levels of IL-6 and IL-8 in serum and amniotic fluid of pregnant women are related to the premature delivery caused by infection.