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目的探究保乳术患者癌及切缘组织中吲哚胺2,3双加氧酶(IDO)、T细胞及微血管密度(MVD)与肿瘤转移复发的关系。方法选取2009年6月至2011年6月收治的64例乳腺癌患者作为本次研究对象,均采用保乳术手术治疗,观察IDO、MVD以及Foxp3在患者乳腺癌组织及切缘组织中表达情况,5年内对所有患者随机走访调查,记录患者5年内无瘤生存率、复发率、远处转移率及病死率等情况,并分析比较。结果患者乳腺癌组织中IDO、Foxp3和MVD指数均显著高于切缘组织(P均<0.01)。患者乳腺癌组织中IDO阳性46例,阴性18例。5年内无瘤生存率IDO阳性患者为71.74%,与阴性患者(94.44%)比较有统计学差异(P<0.05),但总生存率比较无统计学差异(86.96%vs 100.00%,P>0.05)。切缘组织中IDO阳性例数20例(31.25%),阴性为44例(68.75%)。5年内无瘤生存率IDO阳性患者为70.00%,总生存率为80.00%,与阴性患者(81.82%,93.18%)比较差异均无统计学意义(P均>0.05)。64例乳腺癌患者采用保乳术治疗后5年内乳腺癌复发率为10.94%,转移率为15.62%,病死率为9.38%。结论行保乳术的患者癌组织和切缘组织中IDO、Foxp3和MVD水平较高的更易复发,5年内无瘤生存率较低,预后较差。
Objective To investigate the relationship between indoleamine 2,3 dioxygenase (IDO), T cell and microvessel density (MVD) and tumor metastasis and recurrence in carcinoma and marginal tissues of breast conserving surgery. Methods Sixty-four patients with breast cancer who were treated from June 2009 to June 2011 were selected as the study subjects. Surgical treatment of breast-conserving surgery was used to observe the expression of IDO, MVD and Foxp3 in breast cancer tissues and margin tissues All patients were interviewed randomly for 5 years. The 5-year disease-free survival rate, recurrence rate, distant metastasis rate and mortality were recorded and analyzed. Results The IDO, Foxp3 and MVD in breast cancer tissues were significantly higher than those in the marginal tissues (all P <0.01). In patients with breast cancer IDO-positive in 46 cases, 18 cases of negative. The 5-year disease-free survival rate was 71.74% in IDO positive patients and 94.44% in negative patients (P <0.05), but the overall survival rate was no significant difference (86.96% vs 100.00%, P> 0.05 ). There were 20 cases (31.25%) IDO positive cases and 44 cases (68.75%) negative cases in the marginal tissues. The 5-year disease-free survival rate was 70.00% in IDO positive patients and 80.00% in overall survival rates. There was no significant difference between the IDO positive patients and the negative patients (81.82%, 93.18%) (P> 0.05). The breast cancer recurrence rate was 10.94%, the metastasis rate was 15.62% and the case fatality rate was 9.38% in 64 cases of breast cancer patients treated with conservative surgery within 5 years. CONCLUSION: In breast cancer patients, IDO, Foxp3 and MVD in cancer tissues and marginal tissues are more likely to relapse. The 5-year disease-free survival rate is lower and the prognosis is poor.