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研究目的探讨丁胺卡那霉素（丁卡）肾毒性损害的防治。研究方法采用病例对比研究方法。正常对照组儿童50例均测尿常规、尿与血β2M、尿与血mosmol、尿与血THP、尿AIb、尿rGT、尿NAG、肾功能、血清丁卡浓度。研究组43例，均为重症感染患者，其中Ⅰ组（23例）仅用丁卡7天；Ⅱ组（20例）丁卡、维生素C（VC）、维生素E（VE）同时用7天。Ⅰ、Ⅱ两组病例在治疗前、治疗第3天、治疗第7天均作上述实验检查项目。研究结果DAIN发生率Ⅰ组87％（20／23）、Ⅱ组55％（11／20），Ⅱ组显著少于Ⅰ组（P＜0．01）。结论用抗氧化剂药物（VC＋VE）防治了卡致DAIN是有显著疗效的。
Objective To investigate the prevention and treatment of amoxicillin (amikacin) nephrotoxicity induced by amikacin in rabbits. Research methods using case-control study. Urine and blood β2M, urine and blood mosmol, urine and blood THP, urine AIb, urinary rGT, urinary NAG, renal function and serum DKA were measured in 50 normal children. The study group consisted of 43 patients with severe infections, of whom 23 patients in group Ⅰ received Ding card only for 7 days, and 20 patients in group Ⅱ received vitamin C (VC) and vitamin E (VE) for 7 days simultaneously. Ⅰ, Ⅱ two cases before treatment, the first 3 days of treatment, the first 7 days of treatment for the above experimental test items. Results The incidence of DAIN was 87% (20/23) in group Ⅰ, 55% (11/20) in group Ⅱ, and less in group Ⅱ than in group Ⅰ (P <0.01). Conclusion Anti-oxidant drugs (VC + VE) in the prevention and treatment of card-induced DAIN has a significant effect.