脓毒症是由感染或可疑感染引起的全身炎症反应综合征[1],进一步发展可引起严重脓毒症、脓毒症休克和多器官功能障碍综合征(multiple organdysfunction syndrome,MODS)甚至死亡。尽管近年来对脓毒症的研究和认识越来越深入,重症脓毒症及脓毒性休克发病率仍然在上升,2010年的一项研究数据提示在全球每年约有1 800万脓毒症患者[2],全世界每天有近2万名患者死于脓毒症[3], Sepsis is a systemic inflammatory response syndrome caused by an infection or suspicious infection [1], and further development can cause severe sepsis, septic shock and multiple organdysfunction syndrome (MODS) even death. Despite the increasing research and understanding of sepsis in recent years, the incidence of severe sepsis and septic shock is still on the rise. According to a 2010 study data, there are about 18 million sepsis patients in the world each year [2] Nearly 20,000 patients die from sepsis every day in the world [3]