狂犬病是一种严重威胁人民生命的人兽共患的传染病,目前,临床上无特效疗法,病死率几乎百分之百。因此,历来狂犬疫苗的研制和应用倍受重视。1882年巴斯德成功地用连续传代减弱毒力的方法将疯牛病毒(街毒株)经兔脑连续传90代后,改变了其病毒的特性,研制成狂犬病疫苗。该疫苗在全世界广泛应用到本世纪50年代,部分国家和地区沿用至今,这对狂犬病的控制起到了 Rabies is a zoonotic disease that seriously threatens the life of the people. At present, there are no effective treatments clinically and the case fatality rate is almost 100%. Therefore, the history of rabies vaccine development and application of much attention. In 1882, Pasteur succeeded in using successive passages to attenuate virulence. After the mad cow virus (street strain) was continuously transmitted to the rabbit brain for 90 generations, the virus’s characteristics were changed and a rabies vaccine was developed. The vaccine is widely used in the world in the 50s of this century, some countries and regions continue to date, which controls the rabies played