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目的研究复方决明山楂燕麦胶囊对综合因素复制的大鼠脂肪肝的防治作用。方法采用注射10%四氯化碳(CCl4)合并高脂饮食喂养方式建立大鼠脂肪肝模型,以大鼠一般情况、血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)含量、肝脏病理改变为评价指标,观察药物的保护作用。结果与模型组比较,决明山楂燕麦胶囊可非常显著降低大鼠血清ALT含量(P<0.01);显著降低大鼠血清AST含量(P<0.05);并明显改善脂肪肝模型大鼠的肝脏病理改变,减轻肝脏的脂肪变性。结论决明山楂燕麦胶囊对综合因素诱导的大鼠脂肪肝有防治作用。
Objective To study the preventive and therapeutic effects of hawthorn oat capsule of Coptis Decoction on the fatty liver of rats with comprehensive factors replication. Methods Fatty liver rats were established by injection of 10% CCl4 and high-fat diet. The rats were divided into four groups according to their general conditions, serum alanine aminotransferase (ALT), aspartate aminotransferase AST), liver pathological changes for the evaluation of indicators to observe the protective effect of drugs. Results Compared with the model group, hawthorn oat capsule could significantly reduce the serum ALT content (P <0.01), significantly reduce the serum AST content (P0.05), and significantly improve the liver pathology Change, reduce liver fatty degeneration. Conclusion cassia hawkthorn oat capsules on the prevention and treatment of fatty liver induced by a combination of factors.