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目的 为获得全民食用盐加碘前、后合肥市儿童碘营养、甲状腺肿大率及其甲状腺免疫学状况 ,为今后碘盐合理实验依据。方法 以 2 6 44～ 2 395名 7～ 14岁儿童为对象 ,作甲状腺肿大率调查和尿碘、甲状腺肿大者作免疫学测定。结果 食用碘盐前 7～ 14岁儿童甲肿率为 4.0 % (8～ 10岁 3.8% )。肿大的甲状腺均为弥漫 度 ,其过氯酸盐排泌试验阳性率 8.1% ,TGA和 MCA阳性率为 12 .5 % ,尿碘中位数为 79.2μg/ L ,而食用碘盐1年后甲肿率为 7.5 % ,肿大的甲状腺 10 0 %为结节 I°,其过氯酸盐阳性率增至 42 .9% ,TGA、MCA阳性率增至19.6 % ,尿碘中位数 2 6 8.8μg/ L ,且 5 0 0～ 2 0 0 0μg/ L者占 42 % ,前后比均有显著性差异 (P <0 .0 3- 0 .0 0 0 1)。结论 现标准全民碘盐 ,防治碘缺乏病效果良好 ,但有高碘致甲肿和高碘损伤之虑
The purpose is to obtain iodine before and after the national consumption of iodine iodine, Hefei children iodine nutrition, goiter rate and thyroid immunology status for the future iodized salt reasonable experimental basis. Methods A total of 2644 ~ 2395 children aged 7-14 years were enrolled in this study. The goiter rate, urinary iodine and thyroid enlargement were determined by immunological method. Results The iodine salt children 7 ~ 14 years old before the rate of goiter was 4.0% (8 to 10 years old 3.8%). The enlarged thyroid gland was diffuse. The positive rate of perchlorate excretion was 8.1%, the positive rate of TGA and MCA was 12.5%, the median urinary iodine was 79.2μg / L, while the iodine salt was consumed for 1 year The posterior thyroid tumor rate was 7.5%. The enlarged thyroid gland had 10% nodules. The positive rate of perchlorate increased to 42.9%, the positive rate of TGA and MCA increased to 19.6%, and the median urinary iodine 2 8.88μg / L, and those with 500 ~ 200μg / L accounted for 42%. There were significant differences between before and after treatment (P <0.05-0.03.0001). Conclusion Standard iodine salt, iodine deficiency disease prevention and treatment of a good effect, but there is high iodine caused by hypothyroidism and high iodine injury