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目的探讨茵陈合剂对急性肝病患者细胞因子及肠道菌群变化的影响。方法40例患者随机分为对照组(n=20)和治疗组(n=20),常规治疗基础上,治疗组给予茵陈合剂,对照组仅用常规治疗。观察比较治疗组患者血清细胞因子及肠道菌群变化。结果在经过茵陈合剂治疗后,治疗组的肝细胞生长因子(HGF)水平升高,肠道菌群恢复正常,肝功能有所改善,与对照组相比差异有非常显著性(P<0.01)。结论茵陈合剂通过改善肠道菌群,恢复肠道微生态平衡,从而调节细胞因子,有利于肝功能恢复,促进肝细胞的再生。
Objective To investigate the effect of Yinchen mixture on the changes of cytokines and intestinal flora in patients with acute liver disease. Methods Forty patients were randomly divided into control group (n = 20) and treatment group (n = 20). On the basis of conventional treatment, Yinchen Mixture was given to the treatment group and routine treatment was given to the control group. The changes of serum cytokines and intestinal flora in treatment group were observed and compared. Results After treatment with Yinchen mixture, the levels of hepatocyte growth factor (HGF), intestinal flora returned to normal and liver function improved in the treatment group, and the difference was significant compared with the control group (P <0.01) ). Conclusion Yinchen Mixture can improve the intestinal microflora, restore the balance of intestinal microflora and regulate the cytokines, which is good for the recovery of liver function and the regeneration of hepatocytes.