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目的 :评价单层或多层羊膜移植手术治疗严重眼表疾病的临床效果。方法 :对 48例 5 1只眼各类眼表疾病患者采用低温保存 (- 80℃ )人羊膜行单层、双层或多层羊膜移植手术以重建正常眼表结构。结果 :术后随访 3～ 2 0个月 ,44例 47只眼成功再造眼表结构 ,2例 2只眼因角膜缘干细胞严重缺乏 ,术后羊膜植片发生溶解 ,1例 1只眼睑球粘连复发 ,1例 1只眼复发性翼状胬肉再次复发 ,一次手术治愈率为 92 2 %。 2例再次手术行羊膜移植联合健眼角膜缘干细胞组织移植 ,重建眼表获得成功。结论 :羊膜移植手术可有效治疗眼表疾病 ,重建正常眼表结构。对合并角膜缘干细胞严重缺乏的病例 ,羊膜移植应联合角膜缘干细胞移植
OBJECTIVE: To evaluate the clinical efficacy of single or multiple amniotic membrane transplantation in the treatment of severe ocular surface disease. Methods: Forty-eight patients (51 eyes) with ocular surface disease underwent cryopreservation (-80 ℃) human amnion with single, double or multiple amniotic membrane transplantation to reconstruct normal ocular surface structures. RESULTS: After 3 to 20 months of follow-up, 44 eyes (47 eyes) had ocular surface reconstruction, 2 eyes (2 eyes) were severely deficient in limbal stem cells, amniotic membrane lysis occurred in 1 case and 1 case Relapse, 1 case of 1 case of recurrent pterygium relapse again, a surgical cure rate of 92 2%. 2 cases of re-operation of amniotic membrane transplantation combined with corneal limbal stem cells transplantation, reconstructive ocular success. Conclusion: Amniotic membrane transplantation can effectively treat ocular surface diseases and reconstruct normal ocular surface structures. In cases of severe combined limbal stem cell deficiency, amniotic membrane transplantation should be associated with limbal stem cell transplantation