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基于硝酸盐和亚硝酸盐本身或它们的硝化反应特点可能具有潜在的致癌性或致突变性。作者进行了硝酸钠的体内致突变试验以评价这一化合物对大鼠和小鼠骨髓微核和染色体畸变的影响。实验动物共分5组,每组10只大鼠或8只小鼠。其中4组动物给予不同剂量的硝酸钠蒸馏水溶液。部分大鼠(每组4只)和全部小鼠以间隔24小时灌胃给药2次(急性实验)。
Potentially carcinogenic or mutagenic potential may be based on the characteristics of nitrates and nitrites by themselves or their nitration. The authors conducted in vivo mutagenicity tests of sodium nitrate to evaluate the effect of this compound on the micronuclei and chromosomal aberrations in bone marrow of rats and mice. Experimental animals were divided into 5 groups, each group of 10 rats or 8 mice. Four groups of animals were given different doses of sodium nitrate aqueous solution. Some rats (4 in each group) and all mice were given gavage twice a day for 24 hours (acute experiment).