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实验以条件性位置偏爱(CPP)的表达为渴求模型观察纳络酮及MK-801对大鼠食物CPP表达的影响,探讨摄食行为调控的心理机制。48只SD大鼠分成食物组(24)与对照组(24), 3轮食物匹配训练后,在CPP表达前分别注射生理盐水、纳络酮(1. 0mg kg-1 )及MK-801(0. 1mg kg-1 ),观察各组动物在食物匹配训练侧停留时间的变化。结果发现,MK-801促进食物CPP的表达,但纳络酮对食物CPP的表达没有显著影响。以上结果表明MK-801(0. 1mg kg-1 )增强动物的食物渴求至少是其增加摄食量的原因之一,而1. 0mg kg-1的纳络酮降低动物的摄食量并不是由于食物渴求的下降导致的。MK-801与纳络酮调节动物摄食行为的心理机制可能不一致。
In order to investigate the effect of naloxone and MK-801 on the expression of CPP in rats, the psychological mechanism of feeding behavior was investigated by using the conditional place preference (CPP) expression as the craving model. Forty-eight SD rats were divided into two groups: food group (24) and control group (24). After three rounds of food training, normal saline, naloxone (1. 0 mg kg -1) and MK- 0. 1mg kg-1), observe the changes of the residence time of each group of animals in the food match training side. It was found that MK-801 promoted the expression of food CPP, but naloxone had no significant effect on food CPP expression. The above results show that MK-801 (0.1 mg kg-1) enhances animal food craving is at least one of the reasons for its increased food intake, while 1. 0mg kg-1 of naloxone reduced animal intake is not due to food Desperate decline caused. The psychological mechanisms by which MK-801 and naloxone modulate animal feeding behavior may not be consistent.