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目的:本研究旨在通过流行病学研究探讨并分析高同型半胱氨酸血症(HHcy)与动脉硬化相关疾病的关系。方法采用分层、分段、随机、整群的抽样调查方法,抽取北京城乡1460例60岁及以上老年人(男638例,女822例)作为调查对象。采用调查问卷、体格检查的形式获得样本人群动脉硬化相关疾病的患病情况,通过抽血化验测定血浆Hcy水平,并统计分析HHcy与动脉硬化相关疾病的关系。结果 HHcy与高血压(χ~2=19.064,P<0.01)、冠心病(χ~2=12.039,P<0.05)、脑血管病(χ~2=10.947,P<0.05)、糖尿病(χ~2=20.843,P<0.01)、认知功能异常(χ~2=12.402,P<0.05)的患病相关。结论 HHcy与高血压、冠心病、脑血管疾病、糖尿病、认知功能异常的患病率有相关性。Hcy≥10μmol/L增加动脉硬化相关疾病的患病风险。
Purpose: This study aimed to explore and analyze the relationship between hyperhomocysteinemia (HHcy) and arteriosclerosis-related diseases through epidemiological studies. Methods The stratified, segmented, randomized, cluster sampling method was used to select 1460 elderly people aged 60 years and older (638 males and 822 females) in urban and rural areas of Beijing as the survey subjects. The prevalence of atherosclerosis-related diseases in the sample population was obtained by means of questionnaires and physical examinations. Plasma Hcy levels were determined by blood sampling and the relationship between HHcy and arteriosclerosis-related diseases was statistically analyzed. Results HHcy was associated with hypertension (χ ~ 2 = 19.064, P <0.01), coronary heart disease (χ ~ 2 = 12.039, P <0.05), cerebrovascular disease (χ ~ 2 = 10.947, 2 = 20.843, P <0.01), and cognitive dysfunction (χ ~ 2 = 12.402, P <0.05). Conclusions HHcy is associated with the prevalence of hypertension, coronary heart disease, cerebrovascular disease, diabetes and cognitive dysfunction. Hcy≥10μmol / L increased risk of arteriosclerosis-related diseases.