妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)是一种发生在妊娠中晚期的特发性疾病,临床上以皮肤瘙痒、黄疸、血清转氨酶升高、血清总胆酸升高为特点。ICP病因未明,认识尚不统一,发病给临床治疗带来了一定的困难。目前对ICP的处理主要有两种方案:一是明确ICP诊断后,一律采用剖宫产终止妊娠;另一种是采用药物保守治疗待产。 Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease that occurs in the second and third trimester of pregnancy. It is characterized by pruritus, jaundice, elevated serum transaminases, and elevated serum total cholic acid . ICP etiology is unknown, the understanding is not uniform, the incidence of clinical treatment has brought some difficulties. There are currently two main options for the ICP treatment: one is to confirm the termination of pregnancy by cesarean section after a definite ICP diagnosis, and the other is to adopt conservative treatment of drugs.