本文利用反相-HPLC 法测定一系列代表性药物制剂中的对羟苯甲酸甲酯(Methylparaben)、对羟苯甲酸丙酯、对羟苯甲酸丁酯、山梨酸和苯甲酸防腐剂的含量。流动相为水-乙腈混合物,为了达到最佳层析,后者的比例、规格以及用各种酸和缓冲剂调整的量均不相同。本法适用于溶液、混悬剂、软膏、霜剂和洗剂中防腐剂的常规测定或稳定性的检测。文中附表列出上述防腐 In this paper, the contents of methylparaben, propylparaben, butylparaben, sorbic acid and benzoic acid preservatives in a series of representative pharmaceutical preparations were determined by reverse phase-HPLC. The mobile phase is a water-acetonitrile mixture. For optimal chromatography, the latter ratio, size, and amount adjusted with various acids and buffers are all different. This Law applies to the routine determination or stability of preservatives in solutions, suspensions, ointments, creams and lotions. The table lists the above anti-corrosion