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目的 寻求一种可用于过继免疫疗法的高效免疫活性细胞。方法 用多种细胞因子诱生CIK细胞 ,用MTT法测定LAK和CIK细胞杀伤活性。结果 在峰值期CIK细胞杀伤活性均显著高于LAK细胞 (P <0 .0 5 )。结论 CIK细胞与LAK细胞属不同的细胞毒性细胞 ,脐血CIK细胞的高杀伤活性提示其可能成为过继免疫疗法的生力军。
Objective To find a highly effective immunocompetent cell that can be used in adoptive immunotherapy. Methods CIK cells were induced by various cytokines and cytotoxic activity of LAK and CIK cells was measured by MTT assay. Results The killing activity of CIK cells in peak period was significantly higher than that in LAK cells (P <0.05). Conclusions CIK cells and LAK cells belong to different cytotoxic cells. The high killing activity of CIK cells in cord blood suggests that they may become the new force of adoptive immunotherapy.