本实验发现大鼠自然吸入谷尘1个月后,病变很轻;至3个月后,则出现肺间质性肉芽肿和轻度性纤维增生;而气管住入谷尘1个月后则病变较明显,呈小气道慢性炎症和局灶性肉芽肿样病变,少数病灶有纤维化趋势;至3个月后病变反而减轻,仅出现气管、支气管的慢性炎症。这提示不同染尘方法所引起的病变是有区别的,尤其对于含矽量较低且含有生物源性物质的有机粉尘。 This experiment found that rats inhaled grain dust naturally after 1 month, the lesion is very light; to 3 months later, there is interstitial granuloma and mild fibrosis; and trachea into the valley dust after 1 month of disease Obviously, a small airway inflammation and focal granuloma-like lesions, a small number of lesions have fibrosis; to 3 months after the lessening, but only the trachea, bronchial chronic inflammation. This suggests that there are differences between lesions caused by different methods of dusting, especially for organic dust containing a low amount of silicon and containing biogenic materials.