TMP 为一广谱抗菌剂,其抗菌谱与磺胺药相似,对多数敏感菌的抗菌作用较磺胺药强。复方新诺明虽是目前磺胺药与TMP 配伍的最佳复方制剂,但近年来临床发现其皮肤损害发生率甚高(3.5%),轻者为红斑性药疹,重者可发生大疱性表皮松懈萎缩性坏死或剥脱性皮炎,甚至可危及生命。因 TMP is a broad-spectrum antibacterial agent whose antibacterial spectrum is similar to that of sulfonamides and its antibacterial activity is stronger than that of sulfonamides on most sensitive bacteria. Although the compound sulfamethoxazole sulfonamides and TMP compatibility of the best compound, but in recent years the clinical discovery of the high incidence of skin lesions (3.5%), the less the erythema drug eruption, severe cases can occur bullous epidermis Loose atrophic necrosis or exfoliative dermatitis can be life-threatening. because