作为最普遍应用的不孕症治疗药物,克罗米芬(CC)用于诱导排卵已有30余年的历史。CC对人体兼有雌激素兴奋剂和拮抗剂的双重作用。习惯用法为在周期第5d连续给药5d,有部分证据支持这种给药方法。但大量的文献却证明,尽管CC诱发排卵可达90％,但其排卵后的妊娠率却比预期的低。这可能是CC不仅对卵泡和颗粒细胞有作用,还对子宫内膜及宫颈粘液有抗雌激素的作用。一些文献证实,用CC者子宫内膜推迟成熟,宫颈粘液质量欠佳,子宫血流变化明显。这些副作用皆与CC相对较长的半衰期有关。因此,如果开始服用CC的时间迟,由其引起的上述不良作用就更可能延长到着床前。 As the most commonly used treatment for infertility, clomiphene citrate (CC) has been used to induce ovulation for more than 30 years. CC on the human body both estrogen agonists and antagonists dual role. It is customary to have 5 days of continuous administration on the 5th day of the cycle. There is some evidence to support this approach. However, a large number of literatures have proved that despite the ovulation induced by CC up to 90%, but the pregnancy rate after ovulation was lower than expected. This may be CC not only on follicles and granulosa cells have an effect, but also on the endometrium and cervical mucus anti-estrogen effect. Some documents confirm that with CC endometrial postponed mature, poor quality cervical mucus, uterine blood flow changes significantly. These side effects are all related to the relatively long half-life of CC. Therefore, if the time to start taking CC is late, the above mentioned adverse effects caused by it are more likely to be prolonged to pre-implantation.