论文部分内容阅读
目的:探讨血浆同型半胱氨酸(Hcy)水平对老年高血脂患者发生冠心病的预测价值.方法:选择在我院就诊的高血脂患者377例进行研究.记录患者性别、年龄、血糖、血脂、 C反应蛋白(CRP) 、颈动脉内膜中层厚度(IMT) 、 Hcy水平等资料,观察上述指标与冠心病的关系.结果:多因素Logistic回归分析显示:低密度脂蛋白胆固醇(LDL‐C) 、 Hcy 、 IMT是预测冠心病的独立危险因素(O r＝1.205～2.054 , P均＜0.01) .以是否发生冠心病为金标准,绘制Hcy预测冠心病的受试者工作曲线(ROC) ,结果显示, Hcy预测冠心病的的敏感度为82. 9%,特异性为73.3%,最佳截断值为15. 5μmol／L ,曲线下面积为0. 850 ,95% CI为0.810～0.890 .结论:血浆同型半胱氨酸水平对老年高血脂患者冠心病发病具有一定预测价值,值得临床推广应用.“,”Objective :To explore predictive value of plasma homocysteine (Hcy) level for coronary heart disease (CHD) in aged patients with hyperlipidemia .Methods :A total of 377 patients with hyperlipidemia treated in our hospital were selected .Gender ,age ,levels of blood glucose ,blood lipids ,C reactive protein (CRP) ,Hcy and ca‐rotid intima‐media thickness (IMT) etc.were recorded ,and relationship among above indexes and CHD were ob‐served .Results :Multifactor Logistic regression analysis indicated that low density lipoprotein cholesterol ,Hcy and IMT were independent risk factors predicting CHD (O r＝1.205～2.054 , P＜0.01 all).With incidence of CHD as gold stand‐ard ,receiver operating characteristic curve (ROC) of Hcy predicting CHD was drawn ,and the results indicated that sensi‐tivity and specificity of Hcy predicting CHD was 82.9% and 73.3% respectively ,the optimal cutoff point was 15.5μmol／L ,AUC was 0.850 ,and 95% CI was 0.810～0.890. Conclusion :Plasma homocysteine level possesses certain predictive val‐ue for CHD occurrence in aged patients with hyperlipidemia ,which is worth extending .