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本文报导50例无精子症患者睾丸活检观察的结果。分8种组织学类型,其中18例(36%)为阻塞性无精子症;32例(64%)为机能性无精子症(其中6例为睾丸胚胎细胞发育不全和/或成熟不全患者)。讨论了 SCOS 和小管纤维化的类型和发病机理。推测生精小管纤维化可能实际上是血睾屏障发育不全,或生精成熟受阻,生殖细胞崩溃,分解的有害物质和自身抗原引起支持细胞的损伤,有害刺激物作用于管周组织,诱发自身免疫反应和其他组织变化(增生、变性)。并又加剧生精上皮损害,病变发展直至小管硬化性退化为止。
This article reports 50 cases of azoospermic testicular biopsy results. There were 8 histological types, of which 18 (36%) were obstructive azoospermia and 32 (64%) were functional azoospermia (6 were testicular embryonic hypoplasia and / or immaturity) . The types and pathogenesis of SCOS and tubule fibrosis were discussed. Speculated that seminiferous tubule fibrosis may actually dysplasia of the blood testis barrier, or sperm maturation retardation, germ cell collapse, decomposition of harmful substances and self-antigen caused by supporting cell damage, harmful stimuli in the perivascular tissue, induce their own Immune response and other tissue changes (hyperplasia, degeneration). And also exacerbated the damage of the seminiferous epithelium, lesions develop until the tubule sclerosis so far.